Last data update: May 13, 2024. (Total: 46773 publications since 2009)
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Query Trace: Gray AEB[original query] |
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Reactivation of Chagas disease among heart transplant recipients in the United States, 2012-2016
Gray AEB , La Hoz RM , Green JS , Vikram HR , Benedict T , Rivera H , Montgomery SP . Transpl Infect Dis 2018 20 (6) e12996 BACKGROUND: Heart transplantation has been shown to be a safe and effective intervention for progressive cardiomyopathy from chronic Chagas disease. However, in the presence of the immunosuppression required for heart transplantation, the likelihood of Chagas disease reactivation is significant. Reactivation may cause myocarditis resulting in allograft dysfunction and the rapid onset of congestive heart failure. Reactivation rates have been well documented in Latin America; however, there is a paucity of data regarding the risk in non-endemic countries. METHODS: We present our experience with 31 patients with chronic Chagas disease who underwent orthotopic heart transplantation in the United States from 2012-2016. Patients were monitored following a standard schedule. RESULTS: Nineteen of the 31 patients (61%) developed evidence of reactivation. Among the 19 patients, a majority (95%) were identified by laboratory monitoring using polymerase chain reaction testing. One patient was identified after the onset of clinical symptoms of reactivation. All subjects with evidence of reactivation were alive at follow-up (median: 60 weeks). CONCLUSIONS: Transplant programs in the United States are encouraged to implement a monitoring program for heart transplant recipients with Chagas disease. Our experience using a pre-emptive approach of monitoring for Chagas disease reactivation was effective at identifying reactivation before symptoms developed. This article is protected by copyright. All rights reserved. |
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